{"id":11473,"date":"2025-02-16T19:20:06","date_gmt":"2025-02-16T18:20:06","guid":{"rendered":"https:\/\/noaksark.org\/stockholm\/?post_type=projects&p=11473"},"modified":"2025-11-12T08:47:47","modified_gmt":"2025-11-12T07:47:47","slug":"hivreservoaren","status":"publish","type":"projects","link":"https:\/\/noaksark.org\/stockholm\/en\/projekt\/hivreservoaren\/","title":{"rendered":"Hivreservoaren"},"content":{"rendered":"\n

Mellan 2024-2026 \u00e4r vi beviljade medel fr\u00e5n Vinnova f\u00f6r medverkan i ett forskningsprojekt kring hiv-reservoaren. Projektet syftar till att utveckla en banbrytande diagnostisk produkt f\u00f6r att \u00f6vervaka det individuella behovet av antiviral behandling mot hiv. Genom att anv\u00e4nda en ny metod, CAD-seq, kan man uppt\u00e4cka hiv-infekterade celler som \u00e4r kapabla att producera nytt virus, den s\u00e5 kallade reservoaren. M\u00e5let \u00e4r att \u00f6verf\u00f6ra v\u00e5r metod till rutinlabb i form av ett CE-certifierat kit och d\u00e4rmed m\u00f6jligg\u00f6ra att innovationen kommer patienter till godo.<\/strong><\/p>\n\n\n\n

I och med den medicinska utvecklingen och olika forskningsframg\u00e5ngar inom behandling, samsjuklighet, botemedel och vaccin kring hiv blir hiv-reservoarens roll och funktion allt intressantare och viktigare \u2013 f\u00f6r s\u00e5v\u00e4l forskare, kliniker och personer som lever med hiv. \u00d6kad forskning, kunskap och information om hiv-reservoaren handlar om att se bortom CD4 och om\u00e4tbart virus, going beyond undetectable<\/em>, f\u00f6r att f\u00f6rb\u00e4ttra livskvalit\u00e9 och behandlingsutfall f\u00f6r personer som lever med hiv.<\/p>\n\n\n\n

Vad \u00e4r hiv-reservoaren?<\/em> Hiv-reservoaren \u00e4r de infekterade, men vilande eller skadade, celler i kroppen som den anti-virala behandlingen inte n\u00e5r. Dagens anti-virala behandling f\u00f6r personer som lever med hiv \u00e4r idag s\u00e5 effektiv att viruset inte g\u00e5r att m\u00e4ta och att nya hivvirus inte kan bildas. Men behandlingen eliminerar inte hiv-viruset helt i kroppen och behandlingen \u00e4r d\u00e4rf\u00f6r livsl\u00e5ng. Det g\u00f6r att hiv leder till en kronisk infektion \u00e4ven om man \u00e4r smittfri.<\/p>\n\n\n\n

I kroppen hos personer med hiv som har behandling finns infekterade celler som g\u00e5r in i en vilofas (latentfas, sovande virus). Vissa av dessa celler inneh\u00e5ller virusdelar som \u00e4r ofarliga \u00e4ven om man avslutar behandling (trasiga och defekta virusdelar) medan vissa celler inneh\u00e5ller funktionella virusdelar som b\u00f6rjar producera nytt virus om behandlingen avbryts. B\u00e5da dessa celler ing\u00e5r i begreppet hiv-reservoaren. Hiv-reservoaren varierar mellan olika individer och \u00f6ver tid.<\/p>\n\n\n\n

Noaks Ark Stockholms ansvar i projektet \u00e4r att samla in synpunkter och tankar fr\u00e5n patientgruppen till projektgruppen. Detta bland annat genom olika intervjuer och gruppintervjuer med patientgruppen samt sprida kunskap om projektet och hivreservoaren till personer som lever och arbetar med hiv. <\/p>\n\n\n\n

Projektet involverar fyra partners fr\u00e5n olika sektorer och organisationer:<\/p>\n\n\n\n

Karolinska Institutet<\/strong> – projekt\u00e4gare, Peter Svensson<\/p>\n\n\n\n

Medicinsk Diagnostik Karolinska<\/strong> – Annelie Str\u00e5lfors<\/p>\n\n\n\n

Karolinska Universitetssjukhuset<\/strong> – Piotr Nowak, Douglas Carrick, Katarina Stigs\u00e4ter<\/p>\n\n\n\n

Noaks Ark Stockholm<\/strong> – Erica Kanon<\/p>\n\n\n\n

<\/p>\n\n\n\n

Aktiviteter i projektet<\/h2>\n\n\n\n

Webbinarium den 11 november 2025. <\/p>\n\n\n\n

P\u00e5g\u00e5ende referensgruppstr\u00e4ffar 2025-2026.<\/p>\n\n\n\n

\n \n L\u00e4s mer om referensgruppen h\u00e4r <\/a>\n <\/p>\n\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Mellan 2024-2026 \u00e4r vi beviljade medel fr\u00e5n Vinnova f\u00f6r medverkan i ett forskningsprojekt kring hiv-reservoaren. Projektet syftar till att utveckla en banbrytande diagnostisk produkt f\u00f6r att \u00f6vervaka det individuella behovet av antiviral behandling mot hiv….<\/p>\n","protected":false},"featured_media":11474,"template":"","project-status":[150],"class_list":["post-11473","projects","type-projects","status-publish","has-post-thumbnail","hentry","project-status-active"],"acf":[],"yoast_head":"\nHivreservoaren - Noaks Ark Stockholm<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/noaksark.org\/stockholm\/en\/projekt\/hivreservoaren\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hivreservoaren\" \/>\n<meta property=\"og:description\" content=\"Mellan 2024-2026 \u00e4r vi beviljade medel fr\u00e5n Vinnova f\u00f6r medverkan i ett forskningsprojekt kring hiv-reservoaren. 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